Check-in is from 04:00 PM, and check-out is until 10:00 AM. You may request early check-in or late check-out during booking, subject to availability. Guests checking in or out before or after the designated periods may be charged an additional fee. The hotel offers luggage storage to guests for before check-in and after check-out. The front desk is always open, day or night.

Palazzo Guglielmo is easy to access from the airport. In fact, you can even book your airport transfer in advance for greater peace of mind. Just use the "Let us know what you need" section of the booking page to let the hotel know you want to book a ride, and they will contact you via the Agoda messaging service. A stay at Palazzo Guglielmo also comes with easy access to the neighborhoods around the hotel through the convenient shuttle service offered at the hotel. For those who wish to drive their own cars, Palazzo Guglielmo has a car park that's close to the hotel. Parking is free for guests. If you're looking for an easy way to get around Ortelle with private transportation, the hotel can arrange car rental for you.

Palazzo Guglielmo does not permit smoking in any of its rooms, but allows smoking in designated areas.